ASH 2022 | TRIANGLE: ibrutinib with SOC or as a substitute to autologous transplantation in first-line MCL
Manali Kamdar, MD, University of Colorado Cancer Center, Denver, CO, gives an overview of the results of the TRIANGLE study (EudraCT 2014-001363-12) which evaluated the efficacy and safety of adding ibrutinib to standard autologous transplantation or used as a substitute to transplantation in young patients with mantle cell lymphoma (MCL) in the first-line setting. Overall, the study showed a failure-free survival (FFS) benefit in ibrutinib-containing arms, thereby questioning the current standard of care (SOC). This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.
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Disclosures
TG Therapeutics: Consultancy, Research Funding; Genentech: Consultancy, Other: DMC, Research Funding; Novartis: Research Funding; Abbvie: Consultancy; AstraZeneca: Consultancy; BMS: Consultancy; Adaptive Technologies: Consultancy; ADC Therapeutics: Consultancy; Beigene: Consultancy; Impact Bio: Consultancy; SeaGen: Speakers Bureau; Celgene: Other: DMC.
