Iñaki Martín-Subero, PhD, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain, describes a recent publication looking at chromatin activation as the underlying principle in pathogenic mechanisms in multiple myeloma (MM) and chronic lymphocytic leukemia (CLL). This interview took place at the 18th International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Biennial Meeting, held in Edinburgh, UK.