Iñaki Martín-Subero, PhD, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain, reviews the most important insights from the tertiary structure, chromatin modifications and nuclear organisation in chronic lymphocytic leukemia (CLL). This interview took place at the 18th International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Biennial Meeting, held in Edinburgh, UK.