Work showing the complete epigenome of chronic lymphocytic leukemia (CLL) for the first time was released this year, revealing the extent and impact of epigenetic changes involved. We spoke to Iñaki Martín-Subero, PhD, of the Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain, about the results of this interesting analysis. This Interview took place at the European Research Initiative on CLL (ERIC) International Meeting 2018, held in Barcelona, Spain.