Tycel Phillips, MD, University of Michigan, Ann Arbor, MI, reflects on novel approaches in the management of relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL), highlighting the approval of axicabtagene ciloleucel (axi-cel), as well as targeted approaches such as polatuzumab vedotin, an antibody-drug conjugate, in combination with bendamustine and rituximab. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.