Maria-Victoria Mateos, MD, PhD, from the University Hospital of Salamenca, Salamenca, Spain, provides us an overview of the SWOG S0777 trial, a Phase III study evaluating the effectiveness of lenalidomide and dexamethasone with or without bortezomib in treating patients with previously untreated multiple myeloma (MM) (NCT00644228). Here, she also evaluates the role of minimal residual disease (MRD) as a marker for predicting the PFS and OS of MM patients. This interview was filmed at the American Society of Oncology (ASCO) 2017 Annual Meeting in Chicago, IL.