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IMS 2026 | Overcoming challenges in TCR mapping for personalized immunotherapy in multiple myeloma

David Avigan, MD, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, discusses the technical challenges of translating antigen receptor (TCR) mapping into clinical practice. He highlights limitations in current HLA-restricted approaches and peptide selection, while noting the potential for artificial intelligence (AI) and improved databases to identify reliable antigen pairs and help guide treatment decisions. This interview took place at the 23rd International Myeloma Society (IMS) Annual Meeting in Glasgow, UK.

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