At the Myeloma 2015 meeting, Dr Keith Stewart (Mayo Clinic, Scottsdale, AZ) chairs a discussion with Prof Jesús San Miguel (University of Salamanca, Salamanca, Spain) and Prof Antonio Palumbo (University of Torino, Torino, Italy) on new studies of the role of early intervention for smoldering multiple myeloma (MM), treatment strategies for high-risk MM, and promising novel agents for MM.