Claudio Cerchione, MD, PhD, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, discusses the benefit of adding carfilzomib as a third agent to lenalidomide-based doublet regimens in patients with multiple myeloma who are refractory to lenalidomide. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.