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ASH 2022 | Cardiovascular adverse events following treatment with BTK inhibitors in CLL & MCL

Alexey Danilov, MD, PhD, City of Hope, Duarte, CA, comments on the occurrence of cardiovascular adverse events following treatment with BTK inhibitors (BTKi) in patients with chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), highlighting their impact on treatment decisions. Evidence from clinical trials has shown that second-generation agents including acalabrutinib may have a reduced rate of cardiovascular events compared to first-generation agents like ibrutinib. Prof. Danilov also notes that heart disease and other comorbidities are important considerations for the treatment of CLL and other B-cell malignancies. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

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