In this video, Peter Hillmen, MBChB, FRCP, FRCPath, PhD, University of Leeds, Leeds, UK, discusses some results from the Phase III SEQUOIA (BGB-3111-304; NCT03336333) trial, which compared the use of zanubrutinib versus bendamustine and rituximab (BR) therapy in patients with CLL. Dr Hillmen reports on the results of this trial, including the significant improvement observed with the use of zanubrutinib, especially in the IGHV unmutated patient subset. This interview took place at the 63rd ASH Annual Meeting and Exposition Congress, Atlanta, GA, 2021.