Peter Hillmen, MBChB, FRCP, FRCPath, PhD, Apellis Pharmaceuticals, Leeds, UK, talks on the changing landscape of chronic lymphocytic leukemia (CLL). Prof. Hillmen explains that the results of FLAIR (ISRCTN01844152) and GAIA/CLL13 (NCT02950051) trials have clearly demonstrated the superiority of targeted therapy over chemoimmunotherapy and have highlighted the efficacy of therapies combining targeted agents with monoclonal antibodies in patients with CLL. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.