Noemí Puig, MD, PhD, University Hospital Salamanca, Salamanca, Spain, discusses the use of quantitative immunoprecipitation mass spectrometry (QIP-MS) as a measure of minimal residual disease (MRD) in high-risk smoldering myeloma patients enrolled in the GEM-CESAR study (NCT02415413). This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).