Amir Fathi, MD, MPH, Massachusetts General Hospital, Boston, MA, discusses the future of acute myeloid leukemia (AML) treatment in a time when numerous novel agents are showing promise in early phase trials. Dr Fathi comments that, while several therapeutics with unique mechanisms of action appear propitious, mature data is needed before conclusions can be drawn. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.