ASH 2023 | Improvements over time in elderly patients with AML treated with alloSCT: an EBMT Registry study

Ali Bazarbachi, MD, PhD, American University of Beirut, Beirut, Lebanon, shares the findings of a study evaluating the outcomes of allogeneic stem cell transplantation (alloSCT) in older patients with acute myeloid leukemia (AML). Using a large dataset from the EBMT Registry, this study investigated patients with AML who were allografted using a matched sibling donor (MSD), unrelated donor (UD), or haploidentical donor, between the years 2000 and 2021. Results demonstrated that there was an impressive improvement over time in post-transplant outcomes for older patients with AML, with a decrease in cumulative incidence of relapse (CIR) and an increase in leukemia-free survival (LFS), overall survival (OS), as well as graft-versus-host disease (GvHD)-free, relapse-free survival (GRFS). These large-scale, real-world data can serve as a benchmark for future studies. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.

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