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ASCO 2023 | Recent advances in the treatment of patients with myeloma: ADCs, antibodies and CAR-T

Claudio Cerchione, MD, PhD, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, discusses the therapeutic landscape for patients with multiple myeloma, highlighting recent advances in the development of antibody-drug conjugates (ADCs) such as belantamab mafodotin, as well as novel monoclonal antibodies such as daratumumab and isatuximab which target CD38 and have shown efficacy in the relapsed/refractory (R/R) setting. Finally, Dr Cerchione outlines the potential of CAR-T cell therapies and bispecific antibodies. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

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Disclosures

Honoraria – Abbvie; Amgen; BeiGene; Bristol-Myers Squibb/Celgene; GlaxoSmithKline; Janssen; Karyopharm Therapeutics; Menarini; Pfizer; Sanofi/Aventis; SERVIER; Stemline Therapeutics; Takeda Consulting or Advisory Role – Abbvie; Amgen; BeiGene; Bristol-Myers Squibb/Celgene; GlaxoSmithKline; Janssen; Karyopharm Therapeutics; Menarini; Pfizer; Sanofi; SERVIER; Stemline Therapeutics; Takeda Speakers’ Bureau – Abbvie; Amgen; BeiGene; Bristol-Myers Squibb/Celgene; GlaxoSmithKline; Janssen; Karyopharm Therapeutics; Menarini; Pfizer; Sanofi/Aventis; SERVIER; Stemline Therapeutics; Takeda