Christian Chabannon, MD, PhD, Paoli-Calmettes Institute, Marseille, France, discusses the areas that research on CAR T-cell therapy should focus on. To improve clinical performance, CAR T-cell research needs to focus on defining the mechanisms of resistance. In addition to designing CAR-T cells that are more efficient at targeting different antigens. This interview took place during the 2020 Annual Meeting of the International Academy for Clinical Hematology (IACH).