Amir Fathi, MD, MPH, Massachusetts General Hospital Cancer Center, Boston, MA outlines the findings of two dose-escalation and expansion studies. One of the trials investigated the use of the IDH1 inhibitor ivosidenib in IDH1-mutated acute myeloid leukemia (AML) patients. The other looked at the use of enasidenib (ENA) in IDH2-mutated AML. Both trials investigate these regimens in the post-transplant maintenance setting. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.