Maria-Victoria Mateos, MD, PhD, from the University Hospital of Salamenca, Salamenca, Spain, discusses the rationale for analysing the complete response (CR) as the objective for treatment of elderly patients with multiple myeloma (MM). With conventional treatment, few patients achieve CR, as described by Dr. Mateos, but with the development of novel agents, there is potential for using CR as the main objective in the treatment of elderly MM patients. This interview was filmed at the American Society of Oncology (ASCO) 2017 Annual Meeting in Chicago, IL.