Peter Hillmen, MBChB, FRCP, FRCPath, PhD, Apellis Pharmaceuticals, Leeds, UK, compares the health-related quality of life (QoL) outcomes associated with zanubrutinib vs ibrutinib in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) from the ALPINE trial (NCT03734016). The ALPINE trial showed that zanubrutinib was more tolerable than ibrutinib and led to better overall outcomes. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.