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EBMT 2023 | Ruxolitinib combinations in patients with myelofibrosis

Jean-Jacques Kiladjian, MD, PhD, Saint-Louis Hospital & Paris Diderot University, Paris, France, suggests that combining ruxolitinib, a commonly used JAK inhibitor, with drugs that target other pathways involved in disease progression is an effective way to manage difficult-to-treat patients with myelofibrosis (MF). Two promising combinations include pelabresib and navitoclax, which have shown clinical responses and improvements in bone marrow fibrosis and JAK2 allele burden in early-phase trials. Large Phase III randomized trials are currently testing the efficacy of these combinations as first-line therapy. Additionally, a drug called navtemadlin is also being evaluated in a Phase III trial in patients with MF. This interview took place at the 49th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT) held in Paris, France.

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