Maria-Victoria Mateos, MD, PhD, from the Institute of Biomedical Research of Salamanca, Salamanca, Spain, discusses the latest news from the GEM-CESAR trial (NCT02415413) of a curative treatment strategy for high-risk smoldering myeloma: KRD as induction, followed by HDT-ASCT, KRD consolidation and maintenance with RD. This interview took place at the 24th Congress of the European Hematology Association (EHA) 2019, held in Amsterdam, Netherlands.