Graham Jackson, MBBS, FRCP, FRCPath, MD, Newcastle upon Tyne Hospitals NHS Trust, Newcastle, UK, outlines the ever-evolving treatment landscape of myeloma treatment. Specifically discussed is the use of daratumumab, anti-BCMA strategies and the use of quadruplet regimens. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).