Enrique Ocio, MD, PhD, Marqués de Valdecilla University Hospital, Santander, Spain, briefly discusses novel therapeutic agents for the treatment of relapsed/refractory (R/R) multiple myeloma, including cereblon E3 ligase modulators (CELMoDs) such as iberdomide and CC-92480, selinexor, belantamab mafodotin, and other novel targets. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.