Peter Hillmen, MBChB, FRCP, FRCPath, PhD, of the University of Leeds, Leeds, UK, shares an overview of key updates in treatment for chronic lymphocytic leukemia (CLL), including the MURANO (NCT02005471), iLLUMINATE (NCT02264574), ALLIANCE A041202 (NCT01886872), and ECOG-E1912 (NCT02048813) studies, aiming to uncover the most effective initial therapy for CLL. Speaking from the American Society of Hematology (ASH) 2018 Annual Meeting and Exposition in San Diego, CA, Prof. Hillmen describes the superiority of frontline targeted treatments compared with chemotherapy.