Niels van de Donk, MD, PhD, of VU University Medical Center, Amsterdam, Netherlands, talks on the sequencing of B-cell maturation antigen (BCMA)-targeting agents such as antibody-drug conjugates, bispecifics antibodies and chimeric antigen receptor T-cell (CAR-T) therapy. Prof. van de Donk reports that prior BCMA-targeted therapy may impact BCMA expression and therefore recommends having an intermittent line of therapy before going on to another BCMA-targeting therapy where possible. This interview took place during the 18th International Myeloma Workshop (IMW 2021) congress.