ASH 2022 | TRANSFORM: liso-cel versus standard of care as second-line therapy for R/R LBCL
Jeremy Abramson, MD, Massachusetts General Hospital, Boston, MA, presents results from the Phase III TRANSFORM trial (NCT03575351), which is assessing lisocabtagene maraleucel (liso-cel) versus standard of care (SOC) with salvage chemotherapy followed by autologous stem cell transplant (autoSCT) for second-line treatment of relapsed/refractory (R/R) large B-cell lymphoma (LBCL). The study reported superior event-free survival (EFS), progression-free survival (PFS) and complete response (CR) rates in the liso-cel group, with a manageable toxicity profile for liso-cel. This interview took place at the 64th ASH Annual Meeting and Exposition congress held in New Orleans, LA.
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Disclosures
BMS, Seattle Genetics: Research Funding; BMS, AbbVie, Genentech, Epizyme, BeiGene, Kymera, Bluebird Bio, Incyte, Kite Pharma, Genmab, Ono Pharma, Mustang Bio, MorphoSys, Regeneron, Century, AstraZeneca, Lilly, Janssen: Consultancy.
