Anthony Mato, MD, MSCE, Memorial Sloan Kettering Cancer Center, New York, NY, outlines the rationale and results of an international retrospective cohort study of the efficacy of therapies following venetoclax discontinuation in chronic lymphocytic leukemia (CLL). Dr Mato highlights that the therapies they were most interested in included bruton tyrosine kinase inhibitors, phosphoinositide 3-kinase inhibitors and cellular therapy (CAR-T or allo-HSCT). This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.