Sagar Lonial, MD, Emory University School of Medicine, Atlanta, GA, Enrique Ocio, Marquis de Valdecilla University Hospital, Santander, Spain, and Rafael Fonseca, MD, Mayo Clinic, Scottsdale, AZ, speaking at a roundtable meeting at the International Myeloma Workshop (IMW) 2019, held in Boston, MA. The speakers discuss targetted therapy including MCL1 and BCL2 and related clinical trials.