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IMS 2026 | Phase III EXCALIBER-RRMM trial results: iberdomide plus daratumumab in R/R multiple myeloma
Sagar Lonial, MD, Winship Cancer Institute of Emory University, Atlanta, GA, discusses efficacy and safety findings from the Phase III EXCALIBER-RRMM study (NCT04975997) evaluating iberdomide plus daratumumab versus daratumumab and bortezomib in relapsed/refractory (R/R) multiple myeloma. He highlights a higher one-year measurable residual disease (MRD) negativity rate with iberdomide, alongside manageable neutropenia and lower rates of other IMiD-related toxicities. This interview took place at the 23rd International Myeloma Society (IMS) Annual Meeting in Glasgow, UK.
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Transcript
The EXCALIBER-RRMM study is a randomized Phase III trial evaluating iberdomide in combination with daratumumab versus daratumumab with bortezomib. And what we have demonstrated is that the MRD rate at one year is basically double, 40% versus only 20% for dara-Vd. And that in terms of safety, the one thing that is on target is neutropenia. And we see that, and it’s manageable from a clinical perspective...
The EXCALIBER-RRMM study is a randomized Phase III trial evaluating iberdomide in combination with daratumumab versus daratumumab with bortezomib. And what we have demonstrated is that the MRD rate at one year is basically double, 40% versus only 20% for dara-Vd. And that in terms of safety, the one thing that is on target is neutropenia. And we see that, and it’s manageable from a clinical perspective. But all of the other IMiD-related side effects, like fatigue and diarrhea, those are significantly lower than what we saw before. So not only is it more effective, it’s actually got a better safety profile.
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