Uma Borate, MD, Oregon Health & Science University, Portland, OR, outlines novel treatments against myelodysplastic syndromes (MDS). Specifically discussed is the use of antibody-based therapies such as MBG453, small molecule inhibitors such as venetoclax, and therapies including APR246 that targets mutant p53. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).