IMS 2022 | The impact of allosteric HSP70 inhibitors on proteasome inhibitor resistance in multiple myeloma
Arun Wiita
• 26 Sep 2022
Arun Wiita, MD, PhD, University of California, San Francisco, CA, discusses the potential use of allosteric HSP70 inhibitors to overcome proteasome inhibitor resistance in multiple myeloma. Pre-clinical experiments have shown that allosteric HSP70 inhibitors cause degradation of mitochondrial ribosome subunits, which could be used as a therapeutic strategy in patients refractory to first-line therapy. This interview took place at the 19th International Myeloma Society Meeting (IMS) held in Los Angeles, CA.
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