Stephen Nimer, MD, Sylvester Comprehensive Cancer Center and University of Miami, Miami, FL, discusses some of the drug targets for novel treatment options. Specifically, he mentions the potential of using APR246, venetoclax or luspatercept in combination with hypomethylating agents (HMA). This interview took place at the 2nd Regional Symposium on Myelodysplastic Syndromes (MDS 2020), held in Tel Aviv, Israel.