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Stephen Nimer

Academic history

Stephen Nimer is the Director of the Sylvester Comprehensive Cancer Center, Miami, FL and a Professor of Medicine, Biochemistry and Molecular Biology at the University of Miami Miller School of Medicine, Miami, FL. He is also a Fellow of the American College of Physicians, the Chairman of the Myelodysplastic Syndrome Foundation, and the Chairman of the Medical Advisory Board of Gabrielle’s Angel Foundation for Cancer Research.

Prof. Nimer received his medical degree from the University of Chicago Pritzker School of Medicine, Chicago, IL, and subsequently completed a residency in internal medicine at the UCLA Center for Health Sciences, Los Angeles, CA, and a fellowship in hematology/oncology at the David Geffen School of Medicine at UCLA, Los Angeles, CA. Before his current position at the Sylvester Comprehensive Cancer Center, he was a Professor of Medicine at the Memorial Sloan Kettering Cancer Center, New York, NY.

Speaking on hematologic malignancies

Prof. Nimer has conducted extensive research on the treatment and genetic basis of adult leukemia and bone marrow failure states, as well as the regulatory mechanisms that control the production of blood cells. His research group focuses on the transcriptional regulation of normal and malignant hematopoiesis. Through their research, they have established a link between acetylation of the AML1-ETO oncogene and leukemogenesis, as well as overexpression of CARM1 and PRMT5 in acute myeloid leukemia (AML), lymphoma and solid tumors.

Prof. Nimer has also focused on myelodysplastic syndromes (MDS), specifically which mutations or events trigger MDS, which can lead to the development of new personalized therapies. His laboratory is especially interested in understanding the role of histone acetyltransferases, such as p300, in the pathogenesis of MDS.