Saad Usmani, MD, MBBS, MBA, Levine Cancer Institute and Atrium Health, Charlotte, NC, discusses results from the Phase III MAIA trial (NCT02252172), which is investigating daratumumab (dara) plus lenalidomide (len) and dexamethasone (dex) versus len-dex in patients with newly diagnosed multiple myeloma who are transplant-ineligible. At a median follow-up of 36.4 months, dara-len-dex demonstrated a prolonged progression-free survival (PFS) benefit, with median PFS not reached in the dara-len-dex arm. This interview took place during the 47th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT) 2021.