Irene Ghobrial, MD, Dana-Farber Cancer Institute, Boston, MA, discusses the phase 2 trial aimed to determine the progression-free survival and response rate of early therapeutic intervention in patients with high-risk smoldering multiple myeloma (SMM) using the combination of ixazomib, lenalidomide and dexamethasone. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.