Stephen Schuster, MD, Perelman Center for Advanced Medicine, Philadelphia, PA, Ian Flinn, MD, PhD, Johns Hopkins University School of Medicine, Baltimore, MD, Caron Jacobson, MD, Dana-Farber Cancer Institute, Boston, MA, and Frederick Locke, MD, Moffitt Cancer Center, Tampa, FL, are featured in a roundtable discussion on CAR T-cell therapy in lymphoma at the 1st International Workshop on CAR-T, held in Miami, FL. The speakers primarily discuss relapsed diffuse large B-cell lymphoma (DLBCL), including the CAR-T cell therapies axicabtagene ciloleucel and tisagenlecleucel, and share their personal experiences with different CAR-T products, as well as their insights on the future directions of CAR-T in lymphoma.