Prof John Gribben (Barts Cancer Institute, London, UK) interviews Prof Andre Goy (John Theurer Cancer Center, Hackensack, NJ) at the 2014 American Society of Hematology (ASH) Annual Meeting about novel therapies for mantle cell lymphoma (MCL). Topics include novel biologic therapies, such as lenalidomide-based and ibrutinib-based therapies; molecularly distinct MCL subtypes; and treatment of different age groups.