Andre Goy, MD, John Theurer Cancer Center, Hackensack, NJ, shares his highlights from the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting, including the Phase III SHINE trial (NCT01776840) demonstrating for the first time that the addition of ibrutinib to bendamustine-rituximab provides a clinical benefit to patients with mantle cell lymphoma (MCL). Additionally, data on next-generation sequencing (NGS) based on liquid biopsies exploring DNA and RNA signatures illustrated the utility of NGS for stratifying patients with large B-cell lymphoma (LBCL) beyond the standard germinal center (GC) and non-GC classifications. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.