In this session, Gareth Morgan, MD, PhD, FRCP, FRCPath, NYU Langone, New York City, NY, Pieter Sonneveld, MD, PhD, Erasmus University, Rotterdam, Netherlands, and Sagar Lonial, MD, Winship Cancer Institute of Emory University, Atlanta, GA, debate the efforts being undertaken, both in Europe and the US, to support the development of a cure for multiple myeloma. In doing so, they highlight key ongoing studies they hope will advance the treatment of patients with multiple myeloma, as well as current pitfalls in the therapy and research paradigms. This session was filmed at the 16th International Workshop on Multiple Myeloma (iwMyeloma) held in Madrid, Spain.