Niels van de Donk, MD, PhD, of VU University Medical Center, Amsterdam, Netherlands, talks on the potential use of sustained measurable residual disease (MRD) to guide treatment as novel therapies and regimens are increasingly being employed in earlier settings. Prof. van de Donk explains that MRD may be a useful tool to help determine the duration of treatments; however, further research is required. This interview took place during the 18th International Myeloma Workshop (IMW 2021) congress.