Graham Jackson, MBBS, FRCP, FRCPath, MD, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK, briefly discusses the importance of treatment holidays when treating patients with multiple myeloma. Prof. Jackson first highlights the importance of balancing the efficacy of treatment with the wish to give holidays, and further mentions the success of chimeric antigen receptor T-cell (CAR-T) therapy and lenalidomide maintenance therapy, as well as the importance of considering how treatment decisions impact a patient’s quality of life. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.