ICLE 2022 | Assessing existing pre-clinical mouse models for immunotherapies
Juliane Mietz, University Of Zurich, Zurich, Switzerland, describes mouse models used to study immunotherapies in a pre-clinical setting. Cell line-derived xenografts (CDX) and patient-derived xenografts (PDX) originate from established cell lines and the patient’s tumor respectively. CDX models are useful for monitoring tumor growth via a luciferase assay, whilst PDX models retain the physiological features of the tumor. She additionally discusses humanized mice models, which unlike CDX and PDX models, utilize mice with an endogenous immune system created with hematopoietic progenitor cells (HPCs) derived from fetal liver tissue or cord blood. For adults, peripheral blood can also be used to create humanized mice models. This interview took place at the International Conference on Lymphocyte Engineering (ICLE) 2022.
