Great strides have been made in recent years in the engineering of lymphocytes for the treatment of cancer, autoimmune diseases, pathogenic diseases and primary immune deficiencies. Combining gene therapy, cell therapy and immune therapy, the emerging field of lymphocyte engineering employs cutting edge technologies of viral and non-viral vectorology, genome editing and protein design as well as advanced clinical protocols for cell harvest, expansion and re-infusion. With groundbreaking clinical success leading to FDA approved products and with vibrant, exponentially growing research, lymphocyte engineering is the wave of the future. ICLE facilitates the sharing of data and ideas, promotes collaboration, and addresses common challenges to advance clinical translation. The meetings provide an effective environment for active learning, discussions of real-world case studies and for networking between like-minded peers.