Richard Rosenquist, MD, PhD, Karolinska Institute, Stockholm, Sweden, highlights the importance of genomic testing in chronic lymphocytic leukemia (CLL), drawing focus on fluorescence in situ hybridization (FISH) analysis, TP53 mutation screening, and testing of immunoglobin heavy chain gene (IgHV) mutational status. Dr Rosenquist then discusses how these genomic tests are an important part of treatment decision making and allow clinicians to better understand patient outcome in CLL. This interview took place during the 2nd ESH Translational Research Conference on Chronic Lymphocytic Leukemia (ESH CLL), 2022.