Multiple myeloma affects adaptive immunity with neoplastic plasma cells being unable to manufacture the polyclonal immunoglobulins required to fight infections. Additionally, myeloma treatment can raise immunodeficiency, especially during the initial months of treatment or during relapsed disease. In this video, Krina Patel, MD, MSc, MD Anderson Cancer Center, Houston, TX, talks on SARS-CoV-2 in multiple myeloma, highlighting strategies to mitigate negative outcomes. This interview took place during the 2nd Immune Effector Cell Therapy in MM Workshop in Boston, MA.