Abdullah Kutlar, MD, Augusta University, Augusta, GA, talks on the practical aspects of integrating novel agents into clinical practice for the management of sickle cell disease (SCD). Three new agents have been approved in the last four years, transforming the SCD treatment paradigm after nearly 20 years with no new approvals for adult patients. Prof. Kutlar explains how these agents are used in daily practice and why different options are indicated in different scenarios. Prof. Kutlar goes on to share his experience managing patients receiving a combination of agents and how this may represent an important future strategy. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.