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ASH 2021 | Current therapeutic management strategies in sickle cell disease

Abdullah Kutlar, MD, Augusta University, Augusta, GA, shares an overview of recent developments in the rapidly evolving sickle cell disease (SCD) therapeutic landscape. Three new agents have been approved in the last four years after each demonstrated beneficial disease modifying effects. Firstly, L-glutamine was approved in 2017, representing the first new treatment for adult patients in nearly 20 years. Following this, crizanlizumab, an anti-P-selectin monoclonal antibody, and voxelotor, a small molecule anti-sickling agent, were both approved in 2019. Acting via different mechanisms, both these novel agents are used in clinical practice to treat SCD. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.