In this interview, Surbhi Sidana, MD, of the Mayo Clinic, Stanford, CA, discusses glycosylation of immunoglobulin as it relates to cold agglutinin disease (CAD) and how this can signify a risk for amyloidosis development. In this discussion, glycosylation is evaluated as a diagnostic tool for this indication. This interview was recorded via an online conference call with the Video Journal of Hematological Oncology (VJHemOnc).