Surbhi Sidana, MD, Stanford University, Stanford, CA, gives an overview of the toxicities that are associated with immunotherapy with bispecific antibodies and CAR-Ts in the treatment of multiple myeloma (MM). There are currently five FDA-approved immunotherapies, with the most common short-term adverse events (AEs) being cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), hemophagocytic lymphohistiocytosis (HLH)–like toxicities, cytopenias, and infections. Dr Sidana emphasizes the importance of managing CRS in both bispecific and CAR-T treatment rapidly with the use of tocilizumab. Although rare, secondary primary malignancies following CAR-T treatment are being investigated by the FDA. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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